ABSTRACT
The purpose of the present study was to provide a clinical and histologic evaluation of b-tricalciunvphosphate [p-TCP] [cetasotb] alone 01 in combination with autologous platelet gel [APG] in management of osseous defects in chronic periodontitis A total of 16 infrabony interproximal osseous defects were chosen from 10 patients for this study. All patients were subjected to thorough clinical examination in selected sites including plaque index, gingival index, probing depth and probing attachment level. All these clinical parameters were taken prior to surgery and at 3 and 6 months post surgically. The interproximal osseous defects were divided into 2 groups, the first group comprised 8 osseous defects which were treated with full thickness mucoperiosteal flap and filled with cerasorb only. The second group comprised 8 osseous defects which were treated with cerasorb in combination with autologous platelet gel Intra oral standard periapical radiographs using long cone paralleling technique were obtained tor each defect treated in this study pre and 4 months post surgery An experimental study on 6 dogs was also included in this study, 12 surgically produced osseous defects were created in the 6 dogs. Two defects in premolar area in each dog. The defects were made similar as much as possible as regard number of osseous wall remaining depth and width. One defect was filled with cerasorb while the other was filled with cerasorb + platelet gel. 3 dogs were scarified at 2 weeks while the other 3 were scarified at 1 month. Mesio-distal sections were prepared and stained for histological examination It had been found that clinically, both treatment modalities resulted in significant improvement of probing depth and gain of attachment. Histologically, the adjunctive use of p-TCP + APG offered a more impressive regenerative potential than the use of p-TCP alone, thus it is considered to be an effective valuable mode of treatment of infrabony defects in chronic periodontitis
ABSTRACT
Fifteen patients with active SLE participated in this study. They were selected according to the American Rheumatism Association revised criteria for SLE, 15 normal subjects were chosen as controls and were free from any systemic diseases. All the subjects were subjected to the thorough clinical medial examination, routine laboratory investigations for SLE and thorough oral clinical examination. The results showed that clinical dental results showed that there was a significant increase in papillary bleeding index, probing pocket depth and probing attachment level in active SLE, when compared to control group. The immunological results showed that a highly significant increase in IL-4 levels in GCF from SLE compared with the controls. Also, a significant increase in IL-8 levels was found in GCF from SLE compared with control group
Subject(s)
Gingival Crevicular Fluid , Interleukin-4 , Interleukin-8ABSTRACT
The present study was undertaken to determine the effect of a home bleaching agent on various clinical parameters, as well as, on the levels of fibronectin in human GCF and in gingival tissue and bone of dogs. Also, histological changes that occurred in gingival tissue of dogs were studied. The results revealed that the levels of fibronectin in GCF of human was significantly decreased after application of bleaching agent. Also, the levels of FN in gingival tissue and alveolar bone of dogs were significantly decreased in the bleaching site when compared with the control site. Histological study of gingival tissue of dogs revealed variable areas of destruction in the epithelium and connective tissue
Subject(s)
Dental Polishing , Soft Tissue Injuries , Fibronectins , HistologyABSTRACT
A total number of 30 subjects participated in this study, 24 patients with EOP and 6 control subjects. Gingival biopsies were obtained from EOP patients and control group and were prepared for measurement of DNA content and for quantitative assessments of cells in the cell cycle phases. The results showed that no changes were found in DNA content in gingival tissue of EOP patients when compared with control group. Also, a significant difference was observed in cell image analysis of intermitotic phases of cell cycle between PP and RPP when compared with controls in both epithelium and connective tissue cells while no significant difference was observed between JP and PJP when compared with controls
Subject(s)
Gingival Diseases , Genetic MarkersABSTRACT
Twenty patients [their ages ranged from 18 to 45 years] with a localized gingival recession in the anterior teeth [according to class I Miller's Classification] were participated in this study. They were divided into two groups. Group I consisted of 10 patients with localized gingival recession were treated with coronally positioned flap. Group II consisted of 10 patients with localized gingival recession, were treated with coronally positioned flap augmented with connective tissue. The results revealed that both surgical techniques were equally effective in treating of localized gingival recession. No significant difference between the two groups was found when compared six months following surgery
Subject(s)
Humans , Adolescent , Adult , Surgical Flaps , Treatment Outcome , Plastic Surgery ProceduresABSTRACT
Forty male subjects of age ranging between 40-60 years were studied. The subjects were divided into three groups: Group I [10 controlled non-insulin- dependent diabetic patients], group II [10 uncontrolled non-insulin-dependent diabetic patients], and group III [20 healthy controls]. All cases were subjected to clinical dental examination [plaque index, gingival index, retention index], and biochemical study of the kallikrein level in the saliva. The biochemical studies of uncontrolled diabetics showed decreased salivary kallikrein level, which in turn decreased the salivary flow. This decrease was statistically significant. From the present study, it could be concluded that the decrease level of salivary kallikrein in uncontrolled diabetics due to its vasodilation effect on the salivary glands, as well as the salivary glands, may cause changes in the systemic conditions and reflect those changes
Subject(s)
Biomarkers , Periodontal IndexABSTRACT
The present work was carried out to determine the relationship between the PGE2 levels present in the crevicular fluid and those present in the adjacent periodontal tissue in patients with rapidly progressive periodontitis. Twenty subjects were studied in the present work and were divided into two groups: Group 1, 10 persons with clinically normal gingiva as a control group, and group 2, 10 patients with rapidly progressive periodontitis were diagnosed according to the criteria described by Page. All persons selected were subjected to clinical dental examination and biochemical study for PGE2 level and determination in crevicular fluid and gingival tissue. The biochemical results in this investigation showed elevation of PGE2 concentration in the crevicular fluid of patients with rapidly progressive periodontitis as compared with the crevicular fluid of healthy controls, and that increase is causally implicated in the pathogenesis of bone resorption in periodontal diseases. Also, there was significant increase in PGE2 level in the gingival tissue of patients with RPP as compared with healthy controls. There was high degree of correlation between the crevicular fluid and gingival tissue concentration of PGE2 in rapidly progressive periodontitis, indicating that the crevicular fluid PGE2 can be used to reliably predict tissue levels. From the present study, it could be concluded that the use of CF-PGE2 measurement was used as diagnostic tool for identification of periodontal tissue destruction, and the PGE2 level in the crevicular fluid could reflect the concentration in the adjacent gingival tissues